Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide

The susceptibility of the carbonyl group towards nucleophilic attack affords construction various organic compounds. Thus, investigations activation applying greener methodologies are highly important. In present work, among investigated N-halo compounds, N-fluorobenzenesulfonimide (NFSi) has been found as an efficient and selective catalyst in reaction direct esterification aryl alkyl carboxylic acids supported by microwave (MW) irradiation. comprehensive different benzoic mono-, di- tri-carboxy derivatives was performed, whereby significant time reductions were achieved. presented method used NFSi easily manipulatable, non-metal, water- air-tolerant catalyst, allowing simple synthetic isolation procedures energy saving, compared to conventional methodologies. Importantly, contrast under thermal conditions, where compounds behave pre-catalysts, MW-supported protocol, a distinct mechanism proposed that assumes sustainable catalyst. Moreover, scale-up industrially important derivative performed.